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William and Kate share previously unseen wedding photo

<p>Prince William and Kate celebrated their 13th wedding anniversary on Monday by sharing a previously unseen photo from their big day. </p> <p>"13 years ago today!" they captioned the black and white portrait shared across their  social media accounts.</p> <p>The royal bride wore a lace gown designed by Sarah Burton for Alexander McQueen, while the Prince donned his military uniform. </p> <p>This wedding anniversary marks their first since Princess Kate's cancer diagnosis in late March. </p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/C6WDpq3NZmI/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/C6WDpq3NZmI/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by The Prince and Princess of Wales (@princeandprincessofwales)</a></p> </div> </blockquote> <p>Last year the couple released a more casual image, showing the couple on their bikes in Norfolk. The year before that they didn't post anything, and in 2021 they released specially commissioned photos taken at Kensington Palace, to mark their 10th wedding anniversary.</p> <p>The royal couple also released a video back then, featuring all three of their children - Prince George, Princess Charlotte and Prince Louis.</p> <p>The photo was taken by portrait photographer Millie Pilkington, who has taken a few other royal portraits - including Prince George's 10th birthday image last year and a Father's Day image of Prince William and his kids shared last June. </p> <p>Pilkington also took the image of King Charles and Queen Camilla, released by Buckingham Palace last week ahead of the first anniversary of their coronation next month. </p> <p><em>Image: Instagram</em></p> <p> </p>

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What are the most common symptoms of menopause? And which can hormone therapy treat?

<p><em><a href="https://theconversation.com/profiles/susan-davis-10376">Susan Davis</a>, <a href="https://theconversation.com/institutions/monash-university-1065">Monash University</a></em></p> <p>Despite decades of research, navigating menopause seems to have become harder – with conflicting information on the internet, in the media, and from health care providers and researchers.</p> <p>Adding to the uncertainty, a recent <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00462-8/fulltext">series in the Lancet</a> medical journal challenged some beliefs about the symptoms of menopause and which ones menopausal hormone therapy (also known as hormone replacement therapy) can realistically alleviate.</p> <p>So what symptoms reliably indicate the start of perimenopause or menopause? And which symptoms can menopause hormone therapy help with? Here’s what the evidence says.</p> <h2>Remind me, what exactly is menopause?</h2> <p>Menopause, simply put, is complete loss of female fertility.</p> <p>Menopause is traditionally defined as the final menstrual period of a woman (or person female at birth) who previously menstruated. Menopause is diagnosed after 12 months of no further bleeding (unless you’ve had your ovaries removed, which is surgically induced menopause).</p> <p>Perimenopause starts when menstrual cycles first vary in length by seven or more days, and ends when there has been no bleeding for 12 months.</p> <p>Both perimenopause and menopause are hard to identify if a person has had a hysterectomy but their ovaries remain, or if natural menstruation is suppressed by a treatment (such as hormonal contraception) or a health condition (such as an eating disorder).</p> <h2>What are the most common symptoms of menopause?</h2> <p><a href="https://srh.bmj.com/content/early/2024/02/21/bmjsrh-2023-202099.long">Our study</a> of the highest quality menopause-care guidelines found the internationally recognised symptoms of the perimenopause and menopause are:</p> <ul> <li>hot flushes and night sweats (known as vasomotor symptoms)</li> <li>disturbed sleep</li> <li>musculoskeletal pain</li> <li>decreased sexual function or desire</li> <li>vaginal dryness and irritation</li> <li>mood disturbance (low mood, mood changes or depressive symptoms) but not clinical depression.</li> </ul> <p>However, none of these symptoms are menopause-specific, meaning they could have other causes.</p> <p>In <a href="https://journals.lww.com/menopausejournal/abstract/2015/07000/moderate_to_severe_vasomotor_and_sexual_symptoms.6.aspx">our study of Australian women</a>, 38% of pre-menopausal women, 67% of perimenopausal women and 74% of post-menopausal women aged under 55 experienced hot flushes and/or night sweats.</p> <p>But the severity of these symptoms <a href="https://journals.lww.com/menopausejournal/abstract/2015/07000/moderate_to_severe_vasomotor_and_sexual_symptoms.6.aspx">varies greatly</a>. Only 2.8% of pre-menopausal women reported moderate to severely bothersome hot flushes and night sweats symptoms, compared with 17.1% of perimenopausal women and 28.5% of post-menopausal women aged under 55.</p> <p>So bothersome hot flushes and night sweats appear a reliable indicator of perimenopause and menopause – but they’re not the only symptoms. Nor are hot flushes and night sweats a western society phenomenon, as has been suggested. Women in Asian countries are <a href="https://journals.lww.com/menopausejournal/fulltext/2022/05000/prevalence,_severity,_and_associated_factors_in.9.aspx">similarly affected</a>.</p> <p>Depressive symptoms and anxiety are also often linked to menopause but they’re less menopause-specific than hot flushes and night sweats, as they’re common across the entire adult life span.</p> <p>The <a href="https://srh.bmj.com/content/early/2024/02/21/bmjsrh-2023-202099.long">most robust guidelines</a> do not stipulate women must have hot flushes or night sweats to be considered as having perimenopausal or post-menopausal symptoms. They acknowledge that new mood disturbances may be a primary manifestation of <a href="https://www.cell.com/cell/abstract/S0092-8674(23)00905-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867423009054%3Fshowall%3Dtrue">menopausal hormonal changes</a>.</p> <p>The extent to which menopausal hormone changes impact memory, concentration and problem solving (frequently talked about as “brain fog”) is uncertain. <a href="https://www.tandfonline.com/doi/full/10.1080/13697137.2022.2122792">Some studies</a> suggest perimenopause may impair verbal memory and resolve as women transition through menopause. But strategic thinking and planning (executive brain function) <a href="https://www.tandfonline.com/doi/full/10.1080/13697137.2022.2122792">have not been shown to change</a>.</p> <h2>Who might benefit from hormone therapy?</h2> <p>The Lancet papers <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00462-8/fulltext">suggest</a> menopause hormone therapy <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02799-X/fulltext">alleviates</a> hot flushes and night sweats, but the likelihood of it improving sleep, mood or “brain fog” is limited to those bothered by vasomotor symptoms (hot flushes and night sweats).</p> <p>In contrast, the highest quality <a href="https://srh.bmj.com/content/early/2024/02/21/bmjsrh-2023-202099.long">clinical guidelines</a> consistently identify both vasomotor symptoms and mood disturbances associated with menopause as reasons for menopause hormone therapy. In other words, you don’t need to have hot flushes or night sweats to be prescribed menopause hormone therapy.</p> <p>Often, menopause hormone therapy is prescribed alongside a topical vaginal oestrogen to treat vaginal symptoms (dryness, irritation or urinary frequency).</p> <p>However, none of these guidelines recommend menopause hormone therapy for cognitive symptoms often talked about as “brain fog”.</p> <p>Despite musculoskeletal pain being the most common menopausal symptom in <a href="https://journals.lww.com/menopausejournal/abstract/2016/07000/prevalence_and_severity_of_vasomotor_symptoms_and.6.aspx">some populations</a>, the effectiveness of menopause hormone therapy for this specific symptoms still needs to be studied.</p> <p>Some guidelines, such as an <a href="https://www.tandfonline.com/doi/full/10.1080/13697137.2023.2258783">Australian endorsed guideline</a>, support menopause hormone therapy for the prevention of osteoporosis and fracture, but not for the prevention of any other disease.</p> <h2>What are the risks?</h2> <p>The greatest concerns about menopause hormone therapy have been about breast cancer and an increased risk of a deep vein clot which might cause a lung clot.</p> <p>Oestrogen-only menopause hormone therapy is <a href="https://www.nice.org.uk/guidance/ng23">consistently considered</a> to cause little or no change in breast cancer risk.</p> <p>Oestrogen taken with a progestogen, which is required for women who have not had a hysterectomy, <a href="https://www.moh.gov.my/moh/resources/Penerbitan/CPG/Women%20Health/CPG_Management_of_Menopause_2022_e-version-1.pdf">has been associated with a small increase</a> in the risk of breast cancer, although any <a href="https://www.bmj.com/content/bmj/371/bmj.m3873.full.pdf">risk appears to vary</a> according to the type of therapy used, the dose and duration of use.</p> <p>Oestrogen taken orally has also been associated with an increased risk of a deep vein clot, although the risk varies according to the formulation used. This risk is avoided by using estrogen patches or gels <a href="https://www.bmj.com/content/bmj/364/bmj.k4810.full.pdf">prescribed at standard doses</a></p> <h2>What if I don’t want hormone therapy?</h2> <p>If you can’t or don’t want to take menopause hormone therapy, there are also effective non-hormonal prescription therapies available for troublesome hot flushes and night sweats.</p> <p>In Australia, most of these options are “off-label”, although the new medication <a href="https://australianprescriber.tg.org.au/articles/management-of-menopause.html">fezolinetant</a> has just been <a href="https://www.tga.gov.au/resources/artg/401401">approved</a> in Australia for postmenopausal hot flushes and night sweats, and is expected to be available by mid-year. Fezolinetant, taken as a tablet, acts in the brain to stop the chemical neurokinin 3 triggering an inappropriate body heat response (flush and/or sweat).</p> <p>Unfortunately, most over-the-counter treatments promoted for menopause are either <a href="https://srh.bmj.com/content/early/2024/02/21/bmjsrh-2023-202099.long">ineffective or unproven</a>. However, cognitive behaviour therapy and hypnosis <a href="https://journals.lww.com/menopausejournal/abstract/2023/06000/the_2023_nonhormone_therapy_position_statement_of.4.aspx">may provide symptom relief</a>.</p> <p><em>The Australasian Menopause Society has useful <a href="https://www.menopause.org.au/health-info/fact-sheets">menopause fact sheets</a> and a <a href="https://www.menopause.org.au/health-info/find-an-ams-doctor">find-a-doctor</a> page. The <a href="https://www.tandfonline.com/doi/full/10.1080/13697137.2023.2258783">Practitioner Toolkit for Managing Menopause</a> is also freely available.</em><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/225174/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/susan-davis-10376">Susan Davis</a>, Chair of Women's Health, <a href="https://theconversation.com/institutions/monash-university-1065">Monash University</a></em></p> <p><em>Image credits: Getty Images </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/what-are-the-most-common-symptoms-of-menopause-and-which-can-hormone-therapy-treat-225174">original article</a>.</em></p>

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William Shatner shocks hosts simply by revealing his age

<p>In a world where time ticks mercilessly onward, one man has defied the very essence of ageing: the legendary William Shatner, the man who boldly went where no nonagenarian has gone before.</p> <p>As Shatner prepares to celebrate his 93rd trip around the sun, fans worldwide are scratching their heads in disbelief. The reason? Well, it seems that Captain Kirk himself has stumbled upon the fountain of youth and decided to keep it all to himself. </p> <p>The commotion started when Shatner made a <a href="https://www.tiktok.com/@todayshow/video/7347749279865490734?_r=1&_t=8koli3bKC49" target="_blank" rel="noopener">guest appearance</a> on the <em>US Today Show</em>, looking fresher than a daisy in springtime. Fans took to social media to express their shock, with one incredulous viewer commenting, "Damn, he's still sharp and has his hair. I would never have guessed 93." And another chimed in with, "I would've guessed 67 or 68."</p> <p>Forget "live long and prosper"; it seems the new motto is "live long and confound the heck out of everyone".</p> <p>Even the hosts of the<em> Today Show</em> were left flabbergasted by Shatner's youthful glow. They couldn't resist asking the man himself for his secret to longevity. And what pearls of wisdom did he impart? "Don't tell anybody [your age]." Ah, sage advice indeed. It seems the real secret to ageing gracefully is to maintain an air of mystery.</p> <p>But let's rewind to 2021 when Shatner was grilled by a journalist about whether he'd had any "serious work" done. His response? A witty comeback, of course. "No, have you?" Touché, Shatner, touché. And when pressed further, he simply attributed his youthful appearance to good genes, lots of horseback riding and a healthy dose of bewilderment about the world. </p> <p>Despite his apparent disdain for the number 90 ("It's disgusting," he once declared in an interview), Shatner finds himself hurtling towards the ripe old age of 93 with all the grace and poise of a starship navigating through a meteor shower. And if his recent TV appearance is anything to go by, he's showing no signs of slowing down.</p> <p>So let's all take a leaf out of Shatner's playbook, shall we? If anyone asks for the secret to your eternal youth, just give them that trademark Shatner smirk and say: "It's classified."</p> <p><em>Images: NBC | Wikimedia | Tik Tok</em></p>

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Why do I keep getting urinary tract infections? And why are chronic UTIs so hard to treat?

<p><em><a href="https://theconversation.com/profiles/iris-lim-1204657">Iris Lim</a>, <a href="https://theconversation.com/institutions/bond-university-863">Bond University</a></em></p> <p>Dealing with chronic urinary tract infections (UTIs) means facing more than the occasional discomfort. It’s like being on a never ending battlefield against an unseen adversary, making simple daily activities a trial.</p> <p>UTIs happen when bacteria sneak into the urinary system, causing pain and frequent trips to the bathroom.</p> <p>Chronic UTIs take this to the next level, coming back repeatedly or never fully going away despite treatment. <a href="https://www.ncbi.nlm.nih.gov/books/NBK557479/">Chronic UTIs</a> are typically diagnosed when a person experiences two or more infections within six months or three or more within a year.</p> <p>They can happen to anyone, but some are more prone due to their <a href="https://www.urologyhealth.org/urology-a-z/u/urinary-tract-infections-in-adults">body’s makeup or habits</a>. Women are more likely to get UTIs than men, due to their shorter urethra and hormonal changes during menopause that can decrease the protective lining of the urinary tract. Sexually active people are also at greater risk, as bacteria can be transferred around the area.</p> <p>Up to <a href="https://www.urologyhealth.org/urology-a-z/u/urinary-tract-infections-in-adults#Related%20Resources">60% of women</a> will have at least one UTI in their lifetime. While effective treatments exist, <a href="https://www.health.harvard.edu/bladder-and-bowel/when-urinary-tract-infections-keep-coming-back#:%7E:text=Your%20urine%20might%20be%20cloudy,they%20take%20on%20your%20life.">about 25%</a> of women face recurrent infections within six months. Around <a href="https://sciendo.com/article/10.33073/pjm-2019-048?tab=article">20–30%</a> of UTIs don’t respond to standard antibiotic. The challenge of chronic UTIs lies in bacteria’s ability to shield themselves against treatments.</p> <h2>Why are chronic UTIs so hard to treat?</h2> <p>Once thought of as straightforward infections cured by antibiotics, we now know chronic UTIs are complex. The cunning nature of the bacteria responsible for the condition allows them to hide in bladder walls, out of antibiotics’ reach.</p> <p>The bacteria form biofilms, a kind of protective barrier that makes them nearly impervious to standard antibiotic treatments.</p> <p>This ability to evade treatment has led to a troubling <a href="https://theconversation.com/rising-antibiotic-resistance-in-utis-could-cost-australia-1-6-billion-a-year-by-2030-heres-how-to-curb-it-149543">increase in antibiotic resistance</a>, a global health concern that renders some of the conventional treatments ineffective.</p> <p>Antibiotics need to be advanced to keep up with evolving bacteria, in a similar way to the flu vaccine, which is updated annually to combat the latest strains of the flu virus. If we used the same flu vaccine year after year, its effectiveness would wane, just as overused antibiotics lose their power against bacteria that have adapted.</p> <p>But fighting bacteria that resist antibiotics is much tougher than updating the flu vaccine. Bacteria change in ways that are harder to predict, making it more challenging to create new, effective antibiotics. It’s like a never-ending game where the bacteria are always one step ahead.</p> <p>Treating chronic UTIs still relies heavily on antibiotics, but doctors are getting crafty, changing up medications or prescribing low doses over a longer time to outwit the bacteria.</p> <p>Doctors are also placing a greater emphasis on thorough diagnostics to accurately identify chronic UTIs from the outset. By asking detailed questions about the duration and frequency of symptoms, health-care providers can better distinguish between isolated UTI episodes and chronic conditions.</p> <p>The approach to initial treatment can significantly influence the likelihood of a UTI becoming chronic. Early, targeted therapy, based on the specific bacteria causing the infection and its antibiotic sensitivity, may reduce the risk of recurrence.</p> <p>For post-menopausal women, <a href="https://link.springer.com/article/10.1007/s00192-020-04397-z">estrogen therapy</a> has shown promise in reducing the risk of recurrent UTIs. After menopause, the decrease in estrogen levels can lead to changes in the urinary tract that makes it more susceptible to infections. This treatment restores the balance of the vaginal and urinary tract environments, making it less likely for UTIs to occur.</p> <p>Lifestyle changes, such as <a href="https://journals.lww.com/co-nephrolhypertens/FullText/2013/05001/Impact_of_fluid_intake_in_the_prevention_of.1.aspx">drinking more water</a> and practising good hygiene like washing hands with soap after going to the toilet and the recommended front-to-back wiping for women, also play a big role.</p> <p>Some swear by cranberry juice or supplements, though researchers are still figuring out <a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD001322.pub2/full">how effective these remedies truly are</a>.</p> <h2>What treatments might we see in the future?</h2> <p>Scientists are currently working on new treatments for chronic UTIs. One promising avenue is the development of <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052183/pdf/pathogens-12-00359.pdf">vaccines</a> aimed at preventing UTIs altogether, much like flu shots prepare our immune system to fend off the flu.</p> <p>Another new method being looked at is called <a href="https://link.springer.com/article/10.1007/s12223-019-00750-y">phage therapy</a>. It uses special viruses called bacteriophages that go after and kill only the bad bacteria causing UTIs, while leaving the good bacteria in our body alone. This way, it doesn’t make the bacteria resistant to treatment, which is a big plus.</p> <p>Researchers are also exploring the potential of <a href="https://www.mdpi.com/2079-6382/12/1/167">probiotics</a>. Probiotics introduce beneficial bacteria into the urinary tract to out-compete harmful pathogens. These good bacteria work by occupying space and resources in the urinary tract, making it harder for harmful pathogens to establish themselves.</p> <p>Probiotics can also produce substances that inhibit the growth of harmful bacteria and enhance the body’s immune response.</p> <p>Chronic UTIs represent a stubborn challenge, but with a mix of current treatments and promising research, we’re getting closer to a day when chronic UTIs are a thing of the past.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/223008/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><a href="https://theconversation.com/profiles/iris-lim-1204657">I<em>ris Lim</em></a><em>, Assistant Professor, <a href="https://theconversation.com/institutions/bond-university-863">Bond University</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/why-do-i-keep-getting-urinary-tract-infections-and-why-are-chronic-utis-so-hard-to-treat-223008">original article</a>.</em></p>

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Popular TV host diagnosed with same condition as Bruce Willis

<p>Popular American TV host Wendy Williams has shared her diagnosis after being plagued by "hurtful rumours". </p> <p>The 59-year-old's medical team announced in a lengthy statement that she has been diagnosed with aphasia and frontotemporal dementia: the same conditions actor Bruce Willis is battling.</p> <p>The news comes after Williams' family confirmed she had checked in to a facility to treat cognitive issues.</p> <p>“Questions have been raised at times about Wendy’s ability to process information and many have speculated about Wendy’s condition, particularly when she began to lose words, act erratically at times, and have difficulty understanding financial transactions,” her medical team said.</p> <p>They said Williams' symptoms first began in 2023, and was diagnosed with the neurological conditions just weeks later after undergoing a series of tests. </p> <p>Her team said both conditions have “already presented significant hurdles in Wendy’s life”.</p> <p>“Wendy would not have received confirmation of these diagnoses were it not for the diligence of her current care team, who she chose, and the extraordinary work of the specialists at Weill Cornell Medicine,” they said.</p> <p>“Receiving a diagnosis has enabled Wendy to receive the medical care she requires.”</p> <p>Williams chose to share the news to “advocate for understanding” and to “raise awareness” for the difficult conditions. </p> <p>“Unfortunately, many individuals diagnosed with aphasia and frontotemporal dementia face stigma and misunderstanding, particularly when they begin to exhibit behavioural changes but have not yet received a diagnosis,” her team said.</p> <p>“There is hope that with early detection and far more empathy, the stigma associated with dementia will be eliminated, and those affected will receive the understanding, support, and care they deserve and need."</p> <p>“Wendy is still able to do many things for herself. Most importantly she maintains her trademark sense of humour and is receiving the care she requires to make sure she is protected and that her needs are addressed."</p> <p>“She is appreciative of the many kind thoughts and good wishes being sent her way.”</p> <p>The TV presenter has previously been open with her medical battle with Graves’ disease and lymphedema, as well as other significant challenges related to her health.</p> <p><em>Image credits: Getty Images</em></p>

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How to navigate a parent’s cancer diagnosis – like Princes William and Harry will now have to do

<p><em><a href="https://theconversation.com/profiles/lydia-harkin-1510450">Lydia Harkin</a>, <a href="https://theconversation.com/institutions/nottingham-trent-university-1338">Nottingham Trent University</a></em></p> <p>King Charles’ <a href="https://www.bbc.co.uk/news/uk-68209998">cancer diagnosis</a> means the royal family has joined the approximately 3 million families in the UK affected by the disease. His family has already gathered around in support. William, Prince of Wales, has taken over some public duties for his father. And younger son Harry, who lives in California, flew to the UK to visit after the diagnosis was announced.</p> <p>If you, like William and Harry, are navigating a parent’s diagnosis, you are not alone. Around 400,000 people are <a href="https://www.macmillan.org.uk/about-us/what-we-do/research/cancer-statistics-fact-sheet">diagnosed</a> each year. This can be a <a href="https://doi.org/10.1002/pon.4287">frightening</a> and difficult time for families, and can change family dynamics.</p> <p>Adult children may find themselves offering emotional and practical support for a parent in a way that has not been required before, through managing medications and symptoms, travel to medical appointments, help with meal preparation and financial support.</p> <p>It can be rewarding to support a loved one and an important way to actively work together, but it can also be stressful. <a href="https://doi.org/10.1002/pon.4056">Studies have found</a> that family caregivers are generally more anxious and more likely to hide their emotional distress when compared with their family member with cancer.</p> <h2>Being a supportive family, even in conflict</h2> <p>Family support can act as a <a href="https://doi.org/10.1002/ejsp.2333">“social cure”</a> against the stress of a life-changing illness. The social cure theory proposes that being a part of a social group (or multiple groups) has benefits for our health and wellbeing. Social groups, particularly those with whom we strongly identify, like families, provide support and help us to combat times of stress.</p> <p>The key psychological component here is that people feel they belong to and identify with their groups. While undergoing cancer treatment, someone may not be able to participate in their usual social groups – through work or hobbies – as much as they used to. These groups may then become incompatible with a person’s new identity as a cancer survivor.</p> <p>Of course, not all families work together harmoniously, and may be in conflict through divorce, separation or estrangement. Social psychologists have <a href="https://doi.org/10.1111/bjso.12155">found that</a> “incompatible” social groups can lead to poorer mental health.</p> <p>Separated families can still come together and be a helpful social group, but they must offer the kind of support that their loved one needs. To figure this out, it is important to think about the person’s <a href="https://doi.org/10.1002/ejsp.2333">identity</a> within the family.</p> <p>For example, a father may view his identity as an advisor, but a cancer diagnosis requires him to be cared for and to seek advice. He may feel a sense of loss for his typical family role, a loss of meaning and of control.</p> <p>However, if his family communicates openly about the difficulties they are all facing, the father may be able to continue to advise his family, in addition to receiving their advice. This can help to maintain his sense of identity as an advisor within his family, while navigating a new status as a cancer survivor.</p> <h2>Communication and support networks</h2> <p>Cancer throws patients and their loved ones into a complex health system, often for the first time, where medical decisions and terminology become important every day. Understanding <a href="https://doi.org/10.1016/j.ejon.2014.03.012">the “language of cancer”</a> can help families feel more in control after a diagnosis.</p> <p>Equally important is communication within a family. Talking about the cancer, rather than treating it as a taboo topic, can improve <a href="https://doi.org/10.1016/j.ejon.2020.101841">mental health for both patients and their families</a>. It may also be an opportunity to empower patients and their loved ones to seek outside support, such as counselling.</p> <p>Families spread across geographical distances (like the royal family) can offer emotional support through regular phone calls or online tools. During the pandemic, <a href="https://doi.org/10.2196/42172">I developed</a> and trialled an app to help older adults combat loneliness. The app allowed them to see a digital map of their social groups, including family members.</p> <p>Your family member with cancer may feel like a burden. This is a common fear in older adulthood generally. But reminding them of how many people are in their lives – and how many people they support – can combat this feeling.</p> <p>Social media is one way to get more involved in these reciprocal support networks. In my work, families affected by cancer have reported using online communities to <a href="https://doi.org/10.1007/s11764-017-0616-1">better understand what their family is going through</a>. Private social media groups <a href="https://doi.org/10.1177/2055207619898993">dedicated to illness</a> can be helpful spaces to meet other patients and families, share experiences and normalise cancer.</p> <p>Cancer communities exist on <a href="https://doi.org/10.4103%2Fijpvm.IJPVM_36_19">Instagram</a>, on <a href="https://doi.org/10.1007/s00345-018-2254-2">YouTube and X/Twitter</a> and through registered cancer charities like <a href="https://www.macmillan.org.uk/">Macmillan Cancer Support</a>. These online resources all provide a way to build a network following a cancer diagnosis.</p> <p>Just as group identification is important within families, having more groups to connect to can act as a buffer during stressful times and help you all cope with your new reality.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/223214/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><a href="https://theconversation.com/profiles/lydia-harkin-1510450"><em>Lydia Harkin</em></a><em>, Principal Lecturer in Psychology, <a href="https://theconversation.com/institutions/nottingham-trent-university-1338">Nottingham Trent University</a></em></p> <p><em>Image credits: Getty Images </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/how-to-navigate-a-parents-cancer-diagnosis-like-princes-william-and-harry-will-now-have-to-do-223214">original article</a>.</em></p>

Caring

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Are catnip and treats like it safe for cats? Here’s how they affect their minds and moods

<p><em><a href="https://theconversation.com/profiles/mia-cobb-15211">Mia Cobb</a>, <a href="https://theconversation.com/institutions/the-university-of-melbourne-722">The University of Melbourne</a> and <a href="https://theconversation.com/profiles/anne-quain-12802">Anne Quain</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a></em></p> <p>Cats kept indoors can <a href="https://safeandhappycats.com.au/">live a good life</a> when they get access to a variety of positive experiences. Examples include performing natural behaviours, feeling safe at home and using their full sensory capabilities, including their sense of smell.</p> <p>Plants such as catnip, cat thyme and silver vine are potent smelly stimulants that can affect cat minds and moods.</p> <p>Ever wondered if these mind-altering substances are safe gifts for our feline friends? And importantly, is it OK to provide these, or is offering catnip to a cat like offering alcohol to a child?</p> <h2>Catnip, cat thyme and silver vine, oh my!</h2> <p>Owners who are concerned about their cats feeling bored and frustrated might offer them fresh or dried catnip (<em>Nepeta cataria</em>), silver vine (<em>Actinidia polygama</em>), cat thyme (<em>Teucrium marum</em>) or other plant materials such as valerian (<em>Valeriana officinalis</em>) and Tatarian honeysuckle (<em>Lonicera tatarica</em>). These last couple <a href="https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-017-0987-6">could offer an alternative</a> if your cat doesn’t respond to catnip.</p> <p>Toys filled with the leaves or extracts of these plants can cause apparently euphoric behaviour in domestic cats (as well as big cats like leopards and jaguars). Not all cats respond this way to these smells, which is <a href="https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-022-01369-1">believed to have a genetic basis</a>.</p> <h2>Are these treats safe for cats?</h2> <p>Cats have a highly developed sense of smell. Some plants release chemical compounds to deter insects or to attract predators of insects that might otherwise destroy them. This includes <a href="https://www.science.org/doi/10.1126/sciadv.aba0721">nepetalactone</a>, an ingredient isolated from catnip and silver vine.</p> <p>Indeed, <a href="https://www.science.org/content/article/why-cats-are-crazy-catnip">it has been argued </a> that exposure to nepetalactone leads to an increase in feel-good hormones in cats. It may also act as a <a href="https://www.science.org/doi/10.1126/sciadv.abd9135">natural mosquito repellent</a> (note that it does not repel all mosquitoes and is not effective for flea or tick control).</p> <p>This may be why sniffing catnip, silver vine and some other plants causes cats to roll on their backs and rub their chins, cheeks and bodies on the plants. Other <a href="https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-017-0987-6">observed behaviours</a> include: licking, shaking their head while carrying plant material in their mouth, drooling, kicking the plant material with their hind feet, and a “wavelike” motion of the skin over their backs as muscles contract and relax.</p> <p>These responses <a href="https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-017-0987-6">generally don’t last long</a>, usually seconds to minutes, before cats relax or resume their normal behaviour.</p> <p>Rather than becoming addicted to these substances, cats are more likely to become habituated and desensitised, with the plants having less effect over time. When sniffed, these plants <a href="https://www.cell.com/iscience/fulltext/S2589-0042(23)01925-9">appear</a> to have <a href="https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-022-01369-1">no adverse effects</a> on cats.</p> <figure><iframe src="https://www.youtube.com/embed/yNUz4zQTA1E?wmode=transparent&amp;start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe><figcaption><span class="caption">Cats (and a dog!) react to the active compound in catnip and silver vine, nepetalactone.</span></figcaption></figure> <h2>Is it ethical to alter the minds of our cats?</h2> <p>When considering how to improve the lives of animals we care for, we tend to focus on whether the benefits outweigh the potential harms.</p> <p>Despite some marketing claims that these plants activates the brain’s opioid system, delivering a “natural high” for cats, there is no evidence these substances actually alter the minds of cats in the same way as alcohol or other drugs alter the minds of humans.</p> <p>The marketing of these cat treats as “kitty crack” or “<a href="https://www.meowijuana.com/">meowijuana</a>” and silver vine sticks as “<a href="https://www.nekopiapets.com.au/product-page/joycat-cat-cigarettes-silvervine-stick">kitty cigarettes</a>” is likely to deter some people from offering their cats <a href="https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-022-01369-1">this kind of olfactory stimulation</a>.</p> <p>Unlike offering alcohol to a child, though, the evidence suggests our cats are OK when given access to these treats. These items won’t induce psychosis and won’t lead to addiction or withdrawal symptoms. And we don’t need to worry about our cats operating heavy machinery or making important decisions under the influence of mind-altering substances!</p> <p>Provided they can walk away at any time, it seems reasonable to let them opt in to a fun time.</p> <p>In fact, we harness the power of cats’ sense of smell in other ways by using <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435919/">synthetic feline facial pheromones</a>. This can help reduce fear, anxiety and distress in cats. These substances can come in useful in settings such as multi-cat households or when moving house.</p> <h2>How to make sure your cat has the purr-fect time</h2> <p>Offering a range of smells (olfactory stimulation) is just one way to ensure your cat has a varied and interesting life. Here are some tips:</p> <ul> <li> <p>offer cats choices to interact with treats and toys – don’t force them</p> </li> <li> <p>rotate the toys and experiences on offer, so every day offers something fresh</p> </li> <li> <p>offer items that cats can scratch – scratching posts and corrugated cardboard are popular items</p> </li> <li> <p>if you are concerned your cat has swallowed part of a toy or seems unwell, check in with your vet.</p> </li> </ul> <p>Given the short-lived effects of these plant-based olfactory stimulants on cats, it is important that we <a href="https://www.sciencedirect.com/science/article/abs/pii/S0168159119301054">optimise their environment, lifestyle and interactions</a> with humans to improve their welfare. We can’t just rely on catnip or silver vine to give our cats a good life indoors – it’s really up to us!<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/214947/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><a href="https://theconversation.com/profiles/mia-cobb-15211"><em>Mia Cobb</em></a><em>, Research Fellow, Animal Welfare Science Centre, <a href="https://theconversation.com/institutions/the-university-of-melbourne-722">The University of Melbourne</a> and <a href="https://theconversation.com/profiles/anne-quain-12802">Anne Quain</a>, Senior Lecturer, Sydney School of Veterinary Science, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a></em></p> <p><em>Image credits: Getty Images </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/are-catnip-and-treats-like-it-safe-for-cats-heres-how-they-affect-their-minds-and-moods-214947">original article</a>.</em></p>

Family & Pets

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Name that rash: 6 common skin conditions (and how to treat them)

<p><strong>Psoriasis</strong></p> <p><span style="text-decoration: underline;"><em>What psoriasis is like:</em></span> Psoriasis is made of red, scaly plaques that can be itchy and painful. It can show up anywhere but is most commonly found on the scalp, as well as the outside of the elbows and knees. It usually starts between age 10 and 30 and tends to be a chronic condition. “It’s a stubborn disease that waxes and wanes, so people have it for their whole lives,” says dermatologist Paul Cohen.</p> <p><span style="text-decoration: underline;"><em>What causes psoriasis:</em></span> This skin rash is the result of your immune system attacking the skin’s cells, and creating new ones too quickly, which then build up into the plaques. There’s no one single cause, but the condition runs in families. Stress, obesity, smoking and having many infections (particularly strep throat) increase your risk.</p> <p><span style="text-decoration: underline;"><em>How to treat psoriasis:</em></span> The first step is generally topical steroids, which can be used for a week or two at a time to clear up the plaques. For ongoing treatment, people use a synthetic form of vitamin D (which slows skin growth), medicated shampoos and retinoids (a topical version of vitamin A). Daily exposure to sunlight also seems to help, as does moisturising well. For more serious cases, options include oral medications that suppress the immune system and phototherapy done in a doctor’s office with a special light. (Discover more applications of light therapy.)</p> <p><span style="text-decoration: underline;"><em>Possible red flag:</em></span> Serious cases can involve the joints, a condition called psoriatic arthritis. Also, psoriasis increases your chances of having some other diseases, including type 2 diabetes, cardiovascular disease and autoimmune conditions such as Crohn’s – all of which are, like psoriasis, linked to inflammation.</p> <p><strong>Hives</strong></p> <p><span style="text-decoration: underline;"><em>What hives are like:</em></span> Hives are itchy, raised welts that often have a red ring around them. Their most salient characteristic is that they disappear after about a day, only to show up later in a different location. They come in two forms: acute, which lasts six weeks or less, and chronic.</p> <p><span style="text-decoration: underline;"><em>What causes hives:</em></span> Hives are often the result of the body releasing histamine as part of an allergic reaction to drugs, food or some other irritant. They also commonly appear after a viral illness, as a side effect of your immune system revving up to battle the disease. “There are a number of potential triggers,” says dermatologist Katie Beleznay. In most cases, she adds, the specific origin is never determined.</p> <p><span style="text-decoration: underline;"><em>How to treat hives:</em></span> Since hives are a histamine reaction, over-the-counter antihistamines are the first line of defence. If that doesn’t clear them up, ask a doctor if you should use a stronger antihistamine or oral prednisone, an anti-inflammatory medication.</p> <p><span style="text-decoration: underline;"><em>Possible red flag:</em></span> Rarely, people suffer from ongoing outbreaks of hives almost daily for six weeks or more, a condition called chronic idiopathic urticaria (CIU). The treatment for CIU is the same as for regular hives, but in some cases, it can also be a sign of an underlying thyroid disease or cancer.</p> <p><strong>Eczema</strong></p> <p><span style="text-decoration: underline;"><em>What eczema is like:</em></span> Eczema presents as patches of red, scaly skin that are extremely itchy, especially at night. These rashes often appear on the inside of your elbows and knees. If it’s more serious, the skin might blister or look thickened and white in those areas.</p> <p><span style="text-decoration: underline;"><em>What causes eczema:</em></span> Eczema is the result of having a weakened skin barrier, which can lead to inflammation and an overreaction from your immune system. Most people are born with it, and your genes are partly to blame. “You’re more predisposed to eczema if you have a family history of asthma, hay fever or the condition itself,” says Lisa Kellett, a dermatologist in Toronto. Some research also suggests that it might be a reaction to pollution, or to not being exposed to enough germs in childhood. (Kids who have dogs, for example, are less likely to have eczema.)</p> <p><span style="text-decoration: underline;"><em>How to treat eczema:</em></span> For general maintenance, apply a thick, hypoallergenic moisturizer to affected areas immediately after a bath or shower and at night. More serious flares will need topical prescription steroid creams or non-steroid immunosuppressant creams. People with stubborn eczema might also try phototherapy, which uses UVB light to help calm your immune system and reduce itchiness.</p> <p><span style="text-decoration: underline;"><em>Possible red flag:</em></span> Rarely, what looks like eczema is actually skin cancer, as both can appear red and scaly. “The difference with skin cancer is that it doesn’t go away if you use a steroid,” says Kellett.</p> <p><strong>Contact Dermatitis</strong></p> <p><span style="text-decoration: underline;"><em>What contact dermatitis is like:</em></span> Contact dermatitis is a variation of eczema, and it looks similar – red, itchy patches on your skin. But unlike that chronic condition, this skin rash is a reaction to something specific and appears only where the offending object has made contact. “Poison ivy, for instance, will show up as a streak where the branch touched the skin,” says Beleznay.</p> <p><span style="text-decoration: underline;"><em>What causes contact dermatitis:</em></span> Besides poison ivy, other common culprits that can cause the immune system to go into overdrive are face cream, jewellery or fragrances. You can also develop a new intolerance to something you’ve used for a long time, such as Polysporin. If it’s not clear what caused it, your dermatologist can do a patch test, putting small amounts of suspected substances on your skin to see if you react.</p> <p><span style="text-decoration: underline;"><em>How to treat contact dermatitis:</em></span> Contact dermatitis is treated with topical steroids, or a stronger oral one, to calm down your immune system and stop the reaction.</p> <p><span style="text-decoration: underline;"><em>Possible red flag:</em></span> Like eczema, the red and scaly presentation of contact dermatitis could be confused for skin cancer, which is another reason to visit your doctor if you’re not sure what caused it.</p> <p><strong>Rosacea</strong></p> <p><span style="text-decoration: underline;"><em>What rosacea is like:</em></span> As rosacea is a dilation of the blood vessels in your cheeks and nose, it often presents as red, sensitive skin in those places. Another form of the condition also includes bumps that resemble acne. For some people, the skin on their nose thickens, making it appear larger.</p> <p><span style="text-decoration: underline;"><em>What causes rosacea:</em></span> We don’t know what brings rosacea on, but, as with eczema, you’re more likely to have it if others in your family do, too. You’re also prone to acquire the condition if you have sun-damaged skin. “Rosacea usually begins around the age of 35 and gets worse with time,” says Kellett. People often find their flare-ups come after eating or drinking specific things.</p> <p><span style="text-decoration: underline;"><em>How to treat rosacea:</em></span> For many, preventing activation of their rosacea is as simple as avoiding triggers – but that’s easier than it sounds and can be a serious test of a sufferer’s willpower. “Those are often the good things in life,” says Beleznay, citing coffee, spicy foods and alcohol as common aggravators. Some women find that everyday makeup is enough to cover up the cosmetic impact of the condition, while others use prescription creams or laser or light therapy to constrict the blood vessels in the cheeks and reduce redness. For those whose rosacea includes bumps, topical creams or oral antibiotics often get rid of them.</p> <p><span style="text-decoration: underline;"><em>Possible red flag:</em></span> Rarely, what looks like rosacea can be confused for the butterfly rash that’s a symptom of lupus, a serious autoimmune disease. The butterfly rash is named as such because of the shape it makes on the nose and both cheeks.</p> <p><strong>Shingles</strong></p> <p><span style="text-decoration: underline;"><em>What shingles is like:</em></span> Shingles normally starts out as a tingly, numb or bruised feeling in a small area, most commonly a patch on the abdomen. A few days later, a painful skin rash with blisters appears over those places. As the condition follows the path of a nerve, the rash eventually presents as a stripe that lasts from two to six weeks.</p> <p><span style="text-decoration: underline;"><em>What causes shingles:</em></span> This one’s easy: chicken pox. Even once you have fully recovered from that virus, your body never totally beats it; it simply retreats and lies dormant in your nerve cells, where, decades later, it can re-erupt as shingles. You’re more likely to get them if you’re immunocompromised or over 50, the age at which most public health agencies recommend you get the vaccine.</p> <p><span style="text-decoration: underline;"><em>How to treat shingles:</em></span> If you suspect you have shingles, see your doctor immediately. “You have to go right away because studies show that people do much better if the antiviral pills are started within 72 hours of the rash onset,” says Cohen. Additionally, sufferers are often given medication, like a local anaesthetic or codeine, to help control the pain.</p> <p><span style="text-decoration: underline;"><em>Possible red flag:</em></span> The real worry with shingles is that for some people, if it is not contained quickly, the virus can lead to longer-term pain lasting over three months and in some cases over a year. If the skin rash appears on the face, it can even cause blindness.</p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://www.readersdigest.co.nz/healthsmart/name-that-rash-6-common-skin-conditions-and-how-to-treat-them" target="_blank" rel="noopener">Reader's Digest</a>. </em></p>

Body

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Downton Abbey star's shock split

<p>Hugh Bonneville, famous for his role in Downton Abbey, has parted ways with his wife, Lucinda "Lulu" Williams, after 25 years of marriage. This revelation came shortly after Bonneville attended a co-star's wedding without his wedding ring.</p> <p>A spokesperson for the actor confirmed the separation, stating, "I can confirm that Hugh Bonneville and Lulu Williams have separated," as reported by the <em>UK Sun</em>.</p> <p>Sources close to the situation reveal that the decision to split was initiated by Bonneville himself. Williams reportedly felt that their lengthy 25-year marriage had been devalued, given Bonneville's recent focus on various aspects of his life.</p> <p>The source explained, "Hugh has been away from home filming a lot this year. He has lost a bit of weight this summer, he was looking trim, tanned and relaxed."</p> <p>Signs of trouble in their relationship first emerged when the 59-year-old actor attended the wedding of his Downton Abbey co-star, Michelle Dockery, without his wedding ring and without Lulu.</p> <p>Their last public appearance together dates back to April when they attended a gala at the Old Vic Theatre in London.</p> <p>Bonneville had previously praised his estranged wife, referring to her as his "bedrock" and "anchor", according to the <em>UK Sun</em>. He humorously recounted their initial connection, saying, "Lulu was running a marquee company … my mother rang her to hire some chairs or something and said, 'Do you remember Hugh?' and that was how we reconnected," though he jokingly added that it "infuriated" him that he had to "give full credit" to his mother.</p> <p>To commemorate their 20th anniversary, the couple renewed their vows at the Graceland chapel in Las Vegas just five years ago. Bonneville and Williams initially met as teenagers but didn't embark on a romantic relationship until their 30s. They exchanged their vows in November 1998 and share a son, Felix, who is now 20 years old.</p> <p><em>Images: Instagram</em></p>

Relationships

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"Beautiful angel": Serena Williams welcomes second child

<p>Serena Williams and her tech entrepreneur husband, Alexis Ohanian, have welcomed their second baby girl! </p> <p>The couple took to Instagram and TikTok to announce the birth of their "beautiful angel" Adira River Ohanian in a series of family photos and a video. </p> <p>"I'm grateful to report our house is teaming with love: a happy & healthy newborn girl and happy & healthy mama. Feeling grateful," proud dad Ohanian captioned the photo of his wife and first-born Olympia meeting her baby sister for the first time. </p> <p>"@serenawilliams you've now given me another incomparable gift — you're the GMOAT," he said referring to her as a the greatest mum of all time. </p> <p>"Thanks to all the amazing medical staff who took care of my wife & our daughter 🙏 I'll never forget the moment I introduced @olympiaohanian to her baby sister."</p> <p>"Your peace would have been like a river, your well-being like the waves of the sea."</p> <p>Williams also made her own special announcement in a TikTok video. </p> <p>In the clip Williams takes a seat next to Ohanian and her first-born Olympia, before getting up and grabbing Adira and sitting back down to make their family complete. </p> <p>"Welcome my beautiful angel," she captioned the photo. </p> <p>The couple <a href="https://www.oversixty.com.au/lifestyle/family-pets/serena-williams-unveils-exciting-family-news" target="_blank" rel="noopener">first announced</a> their pregnancy at the 2023 Met Gala in a TikTok with the caption: "Was so excited when Anna Wintour invited all three of us to the Met Gala." </p> <p><em>Images: Instagram</em></p>

Family & Pets

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"Am I dreaming?": Prince William serves up burgers from food van

<p>The Prince of Wales has stunned a few unsuspecting customers of a London food truck by serving them burgers. </p> <p>In collaboration with popular YouTube channel<em> Sorted Food</em>, Prince William took part in the stunt to promote The Earthshot Prize, a mission he founded in hopes to repair the planet. </p> <p>They worked together to create a plant-based 'Earthshot burger', which they served to customers, in the clip shared on YouTube. </p> <p>As part of the stunt, Prince William first hid his identity by facing away from the customers, when it was time to serve the food, he turned around with burgers in hand to the shock of the diners. </p> <p>"My brain took three seconds to buffer - am I dreaming?" one said after seeing Prince William serving burgers. </p> <p>"I was lost for words," said another. </p> <p>"I was shell-shocked" said a third. </p> <p>The Prince of Wales also praised last year's Earthshot Prize winners, and explained that the dishes served used three of their innovations, which all represented a solution to help repair the planet. </p> <p>"For those of you who don't know, the Earthshot Prize is there to repair and regenerate the planet. Everything you see here comes from the winners from last year," he said.</p> <p>The ingredients for the burgers were sourced by Indian start-up Kheyti, who support local farmers and help shelter their crops from unpredictable weather events and pests. </p> <p>The burgers were cooked in a cleaner-burning portable stove from Mukuru Clean Stoves, which aims to reduce air pollution, and the food was served on Notpla takeaway containers made from natural and biodegradable materials. </p> <p>This is the verdict from the diners: "the best burger we've ever had."</p> <p>The Prince also joked with diners saying that the global Earthshot Prize started back when he "had hair."</p> <p>"It's designed as an environmental prize tackling the world's greatest environmental problems,"  he said. </p> <p>"We liked the idea that this is a big deal, this is like something we really need to aim for, but it's about saving the planet, not taking us to the moon."</p> <p>He added:  "And there's many people out there who want us to move to the next planet already and I'm like, hang on, let's not give up on this planet yet."</p> <p><em>Images: Kensington Palace/ Sorted Food YouTube</em></p>

Food & Wine

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Robin Williams' children share sweet tribute on his 72nd birthday

<p dir="ltr">Robin Williams’ children took to social media to celebrate their father’s legacy on what would’ve been his 72nd birthday.</p> <p dir="ltr">The late actor, known for raising a generation of children through his iconic films like <em>Jumanji, Mrs. Doubtfire</em> and <em>Dead Poets Society</em>, passed away on the 11th of August 2014 at the age of 63.</p> <p dir="ltr">His daughter, Zelda Williams and son, Zak Williams, both took to social media to celebrate their father’s life.</p> <p dir="ltr">Zak posted a throwback photo of the late actor wearing headphones and smiling at the camera.</p> <p dir="ltr">"Happy 72nd Dad! Was remembering how much I used to love that look you'd give,” he captioned.</p> <p dir="ltr">“That look with a mischievous, loving grin that your friends and loved ones knew so well. Joyous and curious and wondrous. Miss you and love you forever!"</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/Cu-5eLVrcMI/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/Cu-5eLVrcMI/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by Zachary Pym Williams (@zakpym)</a></p> </div> </blockquote> <p dir="ltr">His daughter Zelda on the other hand paid tribute to her dad on Twitter.</p> <p dir="ltr">She shared a photo of her late dad protesting in the 2007 New York Picket line with a sign that read: "SAG WGA ON STRIKE."</p> <p dir="ltr">"Happy birthday to Poppo, who definitely would've been out there fighting the good fight for art and artists today and always,” she captioned the photo, and made a reference to the recent<em> Screen Actors Guild and American Federation of Television and Radio Artists</em> (SAG-AFTRA) strike.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Happy birthday to Poppo, who definitely would’ve been out there fighting the good fight for art and artists today and always. <a href="https://t.co/CNiirB3Qb9">pic.twitter.com/CNiirB3Qb9</a></p> <p>— Zelda Williams (@zeldawilliams) <a href="https://twitter.com/zeldawilliams/status/1682497867511128064?ref_src=twsrc%5Etfw">July 21, 2023</a></p></blockquote> <p dir="ltr">Friends and fans have shared their tributes to the actor, in the comment section of both Twitter and Instagram.</p> <p dir="ltr">“Robin Williams was one of the most beautiful souls to ever grace this earth. Thank you for sharing your dad with us all. We miss him greatly. He’s our whole childhood,” wrote one person on Twitter.</p> <p dir="ltr"><em>Night at the Museum</em> actor Ben Stiller tweeted a simple blue heart in response to the tweet.</p> <p dir="ltr">“The world will never be the same without this beautiful soul. He touched so many lives in his time here. Happy Birthday Robin,” wrote one person on Instagram.</p> <p dir="ltr">“Your dad was such a light in my childhood, even though I never met him personally. Thankful for all the goodness he added to the world for so many of us,” another commented.</p> <p dir="ltr"><em>Image: Instagram</em></p>

Family & Pets

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Do psychedelics really work to treat depression and PTSD? Here’s what the evidence says

<p><em><a href="https://theconversation.com/profiles/sam-moreton-194043">Sam Moreton</a>, <a href="https://theconversation.com/institutions/university-of-wollongong-711">University of Wollongong</a></em></p> <p>As of July 1, authorised psychiatrists have been allowed to prescribe MDMA (the chemical found in “ecstasy”) to treat post-traumatic stress disorder (PTSD), and psilocybin (found in “magic mushrooms”) to treat depression that hasn’t responded to other treatment.</p> <p>Psychedelic therapies have researchers excited because evidence suggests they might have lasting beneficial effects on factors that cause psychological distress beyond the treatment period. These include <a href="https://link.springer.com/article/10.1007/s00213-017-4701-y">feeling disconnected from other people</a>, <a href="https://link.springer.com/article/10.1007/s00213-019-05391-0">fear of death</a>, and <a href="https://www.sciencedirect.com/science/article/pii/S2212144719301140?casa_token=OP6tKGxjPHAAAAAA:NTQ4khgsOY5wmsQ5HzCMcZ4eZ43wQV-sdhUbf5LXFiIeKWNwdonhfCxo77k7QbNk4G69EfX-">rigid ways of thinking</a>.</p> <p>This stands in contrast to most medications for psychological issues, which only directly help while people keep taking them regularly.</p> <p>But how strong is the evidence for psychedelic therapy?</p> <h2>Early promise</h2> <p>Early results from studies around the world have found psychedelic therapy <a href="https://www.ranzcp.org/getmedia/0cf57ea2-0bd7-4883-9155-d2ba1958df86/cm-therapeutic-use-of-mdma-for-ptsd-and-psilocybin-for-treatment-resistant-depression.pdf">might be effective</a> for treating a range of psychological issues.</p> <p>For instance, most studies (<a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2032994">but not all</a>) have found patients tend to report <a href="https://pubmed.ncbi.nlm.nih.gov/37357767/">fewer depression symptoms</a> for periods ranging from several weeks to several months after psilocybin therapy.</p> <p>Similarly, studies have found <a href="https://journals.sagepub.com/doi/10.1177/0269881120965915">reductions in PTSD symptoms</a> three weeks after MDMA therapy.</p> <h2>Not so fast</h2> <p>However, as psychedelic research has grown, <a href="https://pubmed.ncbi.nlm.nih.gov/35243919/">limitations</a> of the research have been identified by researchers both <a href="https://psyarxiv.com/ak6gx/">within</a> and <a href="https://www.sciencefictions.org/p/psychedelics">outside</a> the psychedelic field.</p> <p>One issue is that we aren’t sure whether findings might be due to a <a href="https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/placebo-effect">placebo effect</a>, which occurs when a treatment works because people expect it to work.</p> <p>In clinical trials, participants are often given either a medication or a placebo (inactive) drug – and it’s important they don’t know which they have been given. However, due to the strong effects, it is difficult to prevent participants from knowing whether they have been given a psychedelic drug.</p> <p>Researchers have tried to use a range of different drugs (such as Ritalin) as a placebo in order to “trick” those participants not given a psychedelic into thinking they have received one. But this can be difficult to achieve.</p> <p>In 2021, researchers <a href="https://www.tandfonline.com/doi/full/10.1080/17512433.2021.1933434?casa_token=Dovn7x_rkdUAAAAA%3AsPzBTYNTPnNwqj9NvwN0m9ptrP4x4-c83gp3tGcshs30dWHNnmB_Vx-X5H5Y3pZJdG02IWW6X2E">reviewed</a> clinical trials involving psychedelics such as LSD, psilocybin, and dimethyltryptamine (found in animals and plants) for mood and anxiety disorders. They found trials either had not assessed whether participants guessed correctly which drug they had been given, or that this had been tested and participants tended to guess correctly.</p> <p>More recent trials <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2032994">either don’t measure this</a> or find participants have a <a href="https://journals.sagepub.com/doi/full/10.1177/02698811231154852?casa_token=VsPt344fVGwAAAAA%3AA-i1VPBE1EWyFITWNncZEt876lWMiC7rtTOLJBQnb2pHI2775imUJhrzeSZW6r9doaBeDaj61D0">pretty good idea</a> of whether they’ve had a placebo or a psychedelic drug.</p> <p>Given the publicity and excitement around psychedelic research in recent years, it is likely most participants have <a href="https://culanth.org/fieldsights/the-pollan-effect-psychedelic-research-between-world-and-word">strong beliefs</a> such therapies work. This could lead to a significant placebo effect for participants given a psychedelic dose. Additionally, participants who realise they have received a placebo could experience <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184717/">disappointment and frustration</a>, resulting in worse symptoms. The benefits of a psychedelic may seem even greater when they are compared to the experiences of disappointed participants.</p> <h2>Translating trials to practice</h2> <p>Anecdotally, patients might be motivated to report they have gotten better, even when they haven’t.</p> <p>On a 2021 podcast, one clinical trial participant <a href="https://www.psymposia.com/powertrip/">described</a> how, in hindsight, the information they provided to the trial did not accurately capture the worsening of their symptoms. Trial participants are likely aware their results might affect whether treatments are legalised. They may not want to “ruin” the research by admitting the treatment didn’t work for them.</p> <p>There is also uncertainty about whether the findings from clinical trials mean treatments will work in private practice. There may be a lack of clarity around <a href="https://psyarxiv.com/ak6gx/">how trial participants</a> are recruited and selected. Therefore participants may not represent the typical person with PTSD or treatment-resistant depression.</p> <p>And while <a href="https://journals.sagepub.com/doi/full/10.1177/02698811211069100">the safety of psychedelics</a> within controlled contexts is often emphasised by advocates, less is known about safety of psychedelic therapy <a href="https://www.frontiersin.org/articles/10.3389/fpsyt.2021.737738/full">outside</a> clinical trials.</p> <h2>Resolving issues</h2> <p>These issues do not mean the promising psychedelic research conducted over the past several decades is worthless. Nevertheless, a <a href="https://pubmed.ncbi.nlm.nih.gov/35285280/#full-view-affiliation-1">recent review</a> of the effects of MDMA and psilocybin on mental, behavioural or developmental disorders by Australian researchers concluded the “overall certainty of evidence was low or very low”.</p> <p>Dutch researchers recently drafted a <a href="https://psyarxiv.com/ak6gx/">roadmap for psychedelic science</a> with a checklist for future research to help avoid these pitfalls. When more research is done, it might turn out psychedelic treatments help patients and don’t come with unacceptable harms – we simply don’t know that yet.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/208857/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><a href="https://theconversation.com/profiles/sam-moreton-194043">Sa<em>m Moreton</em></a><em>, Associate Lecturer, School of Psychology, <a href="https://theconversation.com/institutions/university-of-wollongong-711">University of Wollongong</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/do-psychedelics-really-work-to-treat-depression-and-ptsd-heres-what-the-evidence-says-208857">original article</a>.</em></p>

Mind

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Prince William's enormous salary leaked

<p>Prince William's extraordinary salary has been revealed, with the Prince of Wales set to rake in an eight-figure sum for the last six months alone. </p> <p>According to the Duchy of Cornwall’s 2023 annual report, the 41-year-old royal received a private income of just under £6 million (A$11,434,000) this year. </p> <div id="story-primary"> <p>William became the Duke of Cornwall following the death of Queen Elizabeth and his father, Charles’ ascension to the throne, meaning he is now also entitled to any surplus of profits from the dukedom.</p> <p>In the financial year of 2022 to 2023, the Duchy recorded net profits of £24.048 million ($45,800,000), according to the report, which was up £1.02 million ($1,944,260) from £23.024 million ($43,886,000) from the year before.</p> <p>The Prince of Wales would usually be entitled to the full $45.8 million profit as his private income, but because he only became heir halfway through the financial year, he received a fraction of his income. </p> <p>The Palace also asked that as a “one-off associated with the change in Dukes of Cornwall”, the Duchy team retain a proportion of the surplus for “working capital purposes” – i.e. the day-to-day costs of running of the estate.</p> <p>William was therefore left with an income of £5.9 million, or about $11 million AUD for his work. </p> <p>In a foreword for the Duchy’s financial accounts, Prince William paid tribute to his father for leaving an “indelible mark” on the dukedom and promised to work hard to make a difference in his new position.</p> <p>“I am committed to the cause of tackling climate change and I am proud of the estate’s efforts to contribute to this challenge,” William wrote.</p> <p>“If we can also help respond to social challenges such as mental health and homelessness, I will feel my term as Duke has been worthwhile.”</p> <p><em>Image credits: Getty Images</em></p> </div>

Money & Banking

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"Ended for good": Prince William launches project inspired by Lady Di

<p>Prince William has launched his most ambitious project to date, announcing his plan to end homelessness in the UK within five short years. </p> <p>The Prince of Wales set out to visit six areas in the UK that experience different types of homelessness with a distinct set of challenges, outlining a detailed plan to see homelessness eradicated. </p> <p>On his two-day tour, the 41-year-old royal shared that his late mother, Princess Diana, was a big inspiration behind the project, after she helped open William's eyes to the nation-wide problem. </p> <p>In the south London borough of Lambeth, Prince William described how he was inspired by "heart-breaking" visits to shelters he made with his mother as a child. </p> <p>"My first visit to a homelessness shelter was when I was 11 with my mother," he told the Mosaic Clubhouse, which supports people with mental health problems.</p> <p>"The visits we made, left a deep and lasting impression."</p> <p>"I met so many extraordinary people and listened to so many heart-breaking personal stories. Too many people have found themselves without a stable and permanent place to call home."</p> <p>"Through these visits, I have seen first-hand the breadth and complexities of homelessness."</p> <p>William said he hoped the Homewards program would "inspire belief throughout the UK and beyond that homelessness can be ended for good".</p> <p>Prince William's Homewards program focuses on preventing homelessness before it begins, bringing together all organisations working in the sector to create solutions that target local challenges.</p> <p>The launch of the project, which was two years in the making, comes days before what would have been Diana's 62nd birthday on July 1st. </p> <p>A major focus of Homewards will be on providing homes to those who need them.</p> <p>"I am pleased to stand here today at the start of our path to ending homelessness," he said.</p> <p>"Over the next five years, I believe that we have a unique opportunity to develop innovative new solutions and scale tangible impact. This will inspire belief throughout the UK – and beyond – that homelessness can be ended for good."</p> <p><em>Image credits: Getty Images</em></p>

Caring

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10 truly inspirational movies

<p>Have you got a favourite film that just makes you feel good? Inspiring movies come in all shapes and sizes, but often they involve stories of love and strength, overcoming obstacles, or changing people’s lives for the better. See if your favourite fee-good film made our top 10.</p> <p><strong>1. DEAD POETS SOCIETY</strong></p> <p>This film resonates with a lot of people as it shows how much a good teacher can be a role model for the kids they teach. This is one of Robin William’s most well known roles, and even Ethan Hawke makes an appearance.</p> <p><strong>2. A BEAUTIFUL MIND</strong></p> <p>It’s nice to see an action star like Russell Crowe in such a different style of movie. Just like the title suggests, this really is a beautiful film. The fact that the story of the brilliant mathematician who also happens to be a paranoid schizophrenic is true makes it even more moving. It shows how someone who has faced adversity and prejudice can overcome the odds to come out on top as a Nobel Prize winner.</p> <p><strong>3. BILLY ELLIOT</strong></p> <p>Overcoming adversity is nearly always a sure-fire way to move the audience to tears. Not only is Billy trying to do ballet when his father doesn’t approve, but he is also growing up in a single parent family without much money to live on. This is a great film about following your dreams.</p> <p><strong>4. ERIN BROCKOVICH</strong></p> <p>Another true story that shows you how important it is to stand up for the people who need it most. Julia Roberts is great as go-getter Erin Brockovich in this film. The great humour adds a fun element to this film.</p> <p><strong>5. FORREST GUMP</strong></p> <p>One of Tom Hanks most famous roles, Forrest Gump is another story that follows the underdog overcoming obstacles within so many parts of his life. The soundtrack is amazingly nostalgic and takes you back to a simpler time. The supporting cast really brings the story to life too.</p> <p><strong>6. SLUMDOG MILLIONAIRE</strong></p> <p>Underdog alert! Well, slumdog that is. This hugely popular film gives us an insight into life in an Indian slum. It shows that despite abject poverty, it is absolutely possible to find love and happiness. </p> <p><strong>7. THE BLIND SIDE</strong></p> <p>Another great true story with leading lady Sandra Bullock as the tough talking mother. After taking in a homeless boy, the family encourages him to follow his destiny and become a football star. </p> <p><strong>8. IT'S A WONDERFUL LIFE</strong></p> <p>Not just one to watch at Christmas, let this classic inspire you at any time of year. A great film that shows us how easy it is to get caught up in our own problems.</p> <p><strong>9. SOUL SURFER</strong></p> <p>The true-story element is both shocking and moving in this film based on surfer Bethany Hamilton who lost an arm in a shark attack. Despite her horrific ordeal, she didn’t do what most people would have done and quit surfing. Instead she followed her dream to achieve amazing success.</p> <p><strong>10. PAY IT FORWARD</strong></p> <p>A great concept here, about doing something nice for people and not expecting anything back. It could be family, friends or even strangers. The story will really make you think about the way society works.</p> <p><em>Image credit: Shutterstock</em></p>

Movies

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Royal family celebrates Prince William’s birthday with unseen photo

<p dir="ltr">The Royal family have shared a never-before-seen candid snap of King Charles and Prince William to celebrate the Prince’s 41st birthday.</p> <p dir="ltr">The picture, which was posted to Instagram on Wednesday, showed a candid moment between the two royals who shared a laugh as the Prince struggled to fasten an ancient Imperial Mantle over his dad's shoulders.</p> <p dir="ltr">The sweet father and son moment was captured inside Westminster Abbey during the coronation rehearsals last month.</p> <p dir="ltr">The pair were dressed in their suits, with the intimate moment captured just days before the big ceremony.</p> <p dir="ltr">“Wishing The Prince of Wales a very happy birthday today! 🎈” the caption read.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/CtvkOxIMFN2/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/CtvkOxIMFN2/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by The Royal Family (@theroyalfamily)</a></p> </div> </blockquote> <p dir="ltr">The photo comes just days after Prince William and Princess Kate shared <a href="https://www.oversixty.co.nz/lifestyle/family-pets/prince-william-shares-sweet-father-s-day-photo" target="_blank" rel="noopener">new family photos </a>in celebration of Father’s Day.</p> <p dir="ltr">Fans have shared their birthday wishes to Prince William and their praise for the beautiful photo.</p> <p dir="ltr">“This photo isn’t about being royal…This photo is depicting the love between a son and his father… ❤️” wrote one fan.</p> <p dir="ltr">“Happy birthday to The Prince of Wales. Keep on shining William! 💕” wrote another.</p> <p dir="ltr">“What a lovely picture! Happy Birthday your Royal Highness! 👑🥳” wrote a third.</p> <p dir="ltr">“Lovely photo! Happy Birthday to Prince William!” commented a fourth.</p> <p><em>Image: Instagram</em></p>

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Prince William shares sweet Father’s Day photo

<p dir="ltr">Prince William has shared a few sweet snaps with his children in celebration of Father’s Day in the UK.</p> <p dir="ltr">The Prince of Wales took to Instagram to post the wholesome picture of him with Prince George, 9, Princess Charlotte, 8, and Prince Louis, 5, on Sunday to celebrate the annual holiday.</p> <p dir="ltr">“Happy Father’s Day ❤️," he captioned the photo.</p> <p dir="ltr">In the first photo, the royal can be seen wrapping his arms around his two older kids, George and Charlotte, while Louis sat on his lap with a cheeky smile on his face.</p> <p dir="ltr">The second photo showed the royal family’s playful side with Louis wrapping his arms around Prince William, while his siblings laughed at his antics.</p> <p dir="ltr">The royal siblings all wore blue to match their dad. Charlotte looked beautiful in a floral print dress with a pastel blue cardigan, while George looked dashing and mature in a chequered shirt and jeans. Louis looked adorable in a knit sweater, striped shirt and shorts.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/Ctn8MqkNqRV/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/Ctn8MqkNqRV/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by The Prince and Princess of Wales (@princeandprincessofwales)</a></p> </div> </blockquote> <p dir="ltr">The photographs were taken on the Windsor Estate earlier this year by Millie Pilkington, who commented on the post and said, “Thank you so much for entrusting me to take this portrait. Truly honoured.”</p> <p dir="ltr">Fans took to the comments to wish Prince Willam a happy Father’s Day.</p> <p dir="ltr">“What a wholesome photo of a dad and his young kids 😍” wrote one person.</p> <p dir="ltr">“Happy Father's Day to Prince William and all fathers out there!” wrote another.</p> <p dir="ltr">“You can see they love their Dad very much :) I do love how affectionate William is with his children, it’s so important to have them know they are loved!” commented a third.</p> <p dir="ltr">“Charlotte is her late grandma's blueprint, she must make prince William's heart skip a beat every time he looks at her,” one fan noted.</p> <p dir="ltr"><em>Image: Instagram</em></p>

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“The heart of Hollywood” Treat Williams dead at 71

<p dir="ltr">Richard Treat Williams, a Hollywood heavyweight with over 129 acting credits to his name, has passed away at the age of 71.</p> <p dir="ltr">The actor was involved in a tragic accident with a car while riding his motorbike in Dorset, Vermont. Treat was the only person who sustained injuries in the crash, and while a helicopter was called in to airlift him to hospital, he sadly passed away. </p> <p dir="ltr">As Dorset’s fire chief Jacob Gibble told <em>People</em>, investigators believed that the car’s driver had been turning and didn’t notice the motorbike. </p> <p dir="ltr">And Treat’s agent of 15 years, Barry McPherson, said the same while confirming the news to the publication.</p> <p dir="ltr">“He was killed this afternoon. He was making a left or a right [and] a car cut him off," McPherson said. "I'm just devastated. He was the nicest guy. He was so talented.</p> <p dir="ltr">"He was an actor's actor. Filmmakers loved him. He's been the heart of Hollywood since the late 1970s. He was really proud of his performance this year. He's been so happy with the work that I got him. He's had a balanced career."</p> <p dir="ltr">Treat’s family later issued a statement regarding his passing to Deadline, where they shared that “it is with great sadness that we report that our beloved Treat Williams has passed away tonight in Dorset, Vermont after a fatal motorcycle accident. </p> <p dir="ltr">“As you can imagine, we are shocked and greatly bereaved at this time. Treat was full of love for his family, for his life and for his craft, and was truly at the top of his game in all of it. It is all so shocking right now, but please know that Treat was dearly and deeply loved and respected by his family and everyone who knew him. </p> <p dir="ltr">“We are beyond devastated and ask that you respect our privacy as we deal with our grief. To all his fans, please know that Treat appreciated all of you and please continue to keep him in your hearts and prayers.”</p> <p dir="ltr">Treat is survived by his wife of 35 years, Pam Van Sant, and their two children, Gill and Ellie, as well as his significant Hollywood legacy. </p> <p dir="ltr">He was a star across both the screen and stage over the course of his impressive career, with over 50 years of experience behind him. From <em>Prince of the City</em> to<em> A Streetcar Named Desire</em>, <em>Hair</em>, <em>Chicago Fire</em>, <em>Everwood</em>, and <em>Miss Congeniality 2</em>, he’d dipped his toes in a wide variety of content.</p> <p dir="ltr">Treat won over fans and co-workers alike with his presence, and they felt the weight of his passing, taking to social media to share their grief, and to pay tribute to the late star. </p> <p dir="ltr">“We are heartbroken over the passing of beloved … star of <em>Chesapeake Shores</em>, <em>The Christmas House</em> and so much more,” the Hallmark Channel wrote. “We will forever cherish him in our hearts, and extend our condolences to Treat’s family, friends, and loved ones.”</p> <p dir="ltr">“Working with Treat Williams in Mamet’s <em>Speed the Plow</em> at Williamstown in ‘91 was the start of great friendship. Damn it, damn it. Treat, you were the best. Love you,” writer and director Justine Bateman shared. </p> <p dir="ltr">“Treat Williams was a passionate, adventurous, creative man. In a short period of time, he quickly befriended me &amp; his adventurous spirit was infectious. We worked on just 1 film together but occasionally connected over the years. Kind and generous with advice and support. RIP,” actor Wendell Pierce said of Treat. </p> <p dir="ltr">And on behalf of many, actor Billy Baldwin noted down just a handful of the qualities he would remember his friend by, writing that “he truly and deeply cared about what’s going on here in America and around the world. Climate change, social justice, freedom, truth, tolerance… love. Beloved by his family, friends, fans, colleagues… his community. </p> <p dir="ltr">“A terrible loss. You will be missed.”</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">He had it all.<br />Smart.<br />Talented.<br />Funny.<br />Charming.<br />Successful.<br />Handsome.<br />Compassionate.<br />Heart of gold.<br />And that name… Treat Williams.</p> <p>He truly and deeply cared about what’s going on here in America and around the world. Climate change, social justice, freedom, truth, tolerance…… <a href="https://t.co/7cKP4nETTz">pic.twitter.com/7cKP4nETTz</a></p> <p>— Billy Baldwin (@BillyBaldwin) <a href="https://twitter.com/BillyBaldwin/status/1668458525335646208?ref_src=twsrc%5Etfw">June 13, 2023</a></p></blockquote> <p dir="ltr"><em>Images: Getty</em></p>

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Why understanding how spiders spin silk may hold clues for treating Alzheimer’s disease

<p><a href="https://theconversation.com/profiles/michael-landreh-1328287">Michael Landreh</a>, <em><a href="https://theconversation.com/institutions/karolinska-institutet-1250">Karolinska Institutet</a></em> and <a href="https://theconversation.com/profiles/anna-rising-1440132">Anna Rising</a>, <em><a href="https://theconversation.com/institutions/karolinska-institutet-1250">Karolinska Institutet</a></em></p> <p>Really, we should envy spiders. Imagine being able to make silk like they do, flinging it around to get from place to place, always having a <a href="https://pubs.acs.org/doi/10.1021/acsmacrolett.8b00678">strong-as-steel safety line</a> or spinning a comfy hammock whenever they need a rest.</p> <p>The fascinating properties of spider silk make it no wonder that scientists have been trying to unravel its secrets for decades.</p> <p>If we could understand and recreate the spinning process, we could produce artificial spider silk for a <a href="https://www.sciencedirect.com/science/article/abs/pii/S0141813021021292">range of medical applications</a>. For example, artificial silk can help <a href="https://doi.org/10.1016/j.biomaterials.2021.120692">regenerate the nerves that connect our brain and limbs</a>, and can shuttle <a href="https://doi.org/10.1021/acs.biomac.0c01138">drug molecules directly into the cells where they are needed</a>.</p> <figure><iframe src="https://www.youtube.com/embed/zNtSAQHNONo?wmode=transparent&amp;start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe></figure> <p>Spider silk is made of <a href="https://www.sciencedirect.com/topics/engineering/spidroins">proteins called spidroins</a>, which the spider stores in a silk gland in its abdomen. There are several types of spidroin for spinning different sorts of silk. Spiders <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673682/">store them as a liquid</a> that resembles oil droplets.</p> <p>But one of the questions that has eluded scientists so far is how spiders turn these liquid droplets into silk. We decided to investigate why the spidroins form droplets, to get us closer to replicating a spider’s spinning process.</p> <h2>Weaving a web</h2> <p>The trick that spiders use to speed up their spinning process can be used to spin better artificial silk, or even develop new spinning processes.</p> <p>In 2017, we learned to <a href="https://www.nature.com/articles/ncomms15504">make synthetic silk fibres</a> by emulating the silk gland, but we did not know how things work inside the spider. Now we know that forming droplets first <a href="https://pubmed.ncbi.nlm.nih.gov/37084706/">speeds up the conversion to these fibres</a>.</p> <p>An important clue to how the droplets and fibres are related came from an unexpected area of our research – on <a href="https://pubmed.ncbi.nlm.nih.gov/23013511/">Alzheimer’s and Parkinson’s diseases</a>. Proteins that are involved in these diseases, called <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/alpha-synuclein#:%7E:text=%CE%B1%2DSynuclein%20is%20a%20highly,linked%20to%20familial%20Parkinson%20disease.">alpha-synuclein</a> and <a href="https://www.alz.org/media/Documents/alzheimers-dementia-tau-ts.pdf">tau</a>, can assemble into tiny, oil-like droplets in human cells.</p> <p>Tau is a protein that helps stabilise the internal skeleton of nerve cells (neurons) in the brain. This internal skeleton has a tube-like shape through which nutrients and other essential substances travel to reach different parts of the neuron.</p> <p>In Alzheimer’s disease, an abnormal form of tau builds up and clings to the normal tau proteins, creating “tau tangles”.</p> <p>Alpha-synuclein is found in large quantities in <a href="https://www.webmd.com/mental-health/what-is-dopamine">dopamine-producing nerve cells</a>. Abnormal forms of this protein are linked to Parkinson’s disease.</p> <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/528217/original/file-20230525-25-p40y48.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/528217/original/file-20230525-25-p40y48.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/528217/original/file-20230525-25-p40y48.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=400&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/528217/original/file-20230525-25-p40y48.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=400&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/528217/original/file-20230525-25-p40y48.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=400&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/528217/original/file-20230525-25-p40y48.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=503&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/528217/original/file-20230525-25-p40y48.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=503&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/528217/original/file-20230525-25-p40y48.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=503&amp;fit=crop&amp;dpr=3 2262w" alt="Beautiful spider web with water drops close-up" /></a><figcaption><span class="caption">The trick spiders use to speed up their spinning process can be used to spin better artificial silk.</span> <span class="attribution"><a class="source" href="https://www.shutterstock.com/image-photo/beautiful-spider-web-water-drops-close-155560781">Aastels/Shutterstock</a></span></figcaption></figure> <p>Oil droplets of either one of these proteins form in humans when they become entangled, like boiled spaghetti on a plate. At first, the proteins are flexible and elastic, much like spidroin oil droplets.</p> <p>But if the proteins remain entangled, they get stuck together which alters their shape, changing them into rigid fibres. These can be toxic to human cells – for example, in neurodegenerative conditions such as Alzheimer’s.</p> <p>However, <a href="https://pubmed.ncbi.nlm.nih.gov/33148640/">spidroins can form droplets</a> too. This left us wondering if the same mechanism that causes neurodegeneration in humans could help the spider to convert liquid spidroins into rigid silk fibres.</p> <p>To find out, we used a <a href="https://www.nature.com/articles/nchembio.2269">synthetic spidroin called NT2RepCT</a>, which can be produced by bacteria. Under the microscope, we could see that this synthetic spidroin formed liquid droplets when it was dissolved in phosphate buffer, a type of salt found in the spider’s silk gland. This allowed us to replicate spider silk spinning conditions in the lab.</p> <h2>Silky science</h2> <p>Next, we studied how the spidroin proteins act when they form droplets. To answer this question, we turned to an analysis technique <a href="https://www.britannica.com/science/mass-spectrometry">called mass spectrometry</a>, to measure how the weight of the proteins changed when they formed droplets. To our surprise, we saw that the spidroin proteins, which normally form pairs, instead split into single molecules.</p> <p>We needed to do more work to find out how these protein droplets help spiders spin silk. Previous research has shown spidroins have different parts, called domains, with separate functions.</p> <p>The end part of the spidroin, called c-terminal domain, makes it form pairs. The c-terminal also starts <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001921">fibre formation when it comes into contact with acid</a>.</p> <p>So, we made a spidroin which contained only the c-terminal domain and tested its ability to form fibres.</p> <p>When we used phosphate buffer to entangle the proteins into droplets, they turned into rigid fibre instantly. When we added acid without first making droplets, fibre formation took much longer.</p> <p>This makes sense since the spidroin molecules must find each other when forming a fibre. Entangling the spidroins like spaghetti helps them rapidly assemble into silk.</p> <p>This finding tells us how the spider can instantly convert its spidroins into a solid thread. It also uncovered how nature uses the same mechanism that can make brain proteins toxic to create some of its most amazing structures.</p> <p>The surprising parallel between spider silk spinning and fibres toxic to humans could one day lead to new clues about how to fight neurodegenerative disorders.</p> <p>Scientists may use spider silk research, including what we have learned about the spider silk domains, to keep human proteins from sticking together – to stop them from becoming toxic. If spiders can learn how to keep their sticky proteins in check, perhaps so can we.<!-- Below is The Conversation's page counter tag. 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More info: https://theconversation.com/republishing-guidelines --></p> <p><a href="https://theconversation.com/profiles/michael-landreh-1328287">Michael Landreh</a>, Researcher, Department of Microbiology, Tumor and Cell Biology, <em><a href="https://theconversation.com/institutions/karolinska-institutet-1250">Karolinska Institutet</a></em> and <a href="https://theconversation.com/profiles/anna-rising-1440132">Anna Rising</a>, Researcher in Veterinary medicine biochemistry, <em><a href="https://theconversation.com/institutions/karolinska-institutet-1250">Karolinska Institutet</a></em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/why-understanding-how-spiders-spin-silk-may-hold-clues-for-treating-alzheimers-disease-205857">original article</a>.</em></p> <p><em>Images: Getty</em></p>

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